Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis
Open Access
- 1 October 1990
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 62 (4) , 637-642
- https://doi.org/10.1038/bjc.1990.345
Abstract
Fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mCi of a 131I radiolabelled monoclonal antibody (MoAb), chosen for its immunoreactivity to tumour. Major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). Nine patients were evaluable for either a tumour or clinical response. Six of these demonstrated an event-free response that was maintained for periods of between 7 and 26 months.Keywords
This publication has 30 references indexed in Scilit:
- Monoclonal Antibodies M340 and UJ181.4 Recognize Antigens Associated with Primitive Neuroectodermal Tumours/TissuesHybridoma, 1989
- Limitations to the killing of tumours using radiolabelled antibodiesThe British Journal of Radiology, 1987
- Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb B72.3International Journal of Cancer, 1987
- Cranial irradiation in childhood lymphoblastic leukemia: time for reappraisal.BMJ, 1985
- Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy.Journal of Clinical Investigation, 1983
- Biological characterization and clinical applications of a monoclonal antibody recognizing an antigen restricted to neuroectodermal tissuesInternational Journal of Cancer, 1983
- Immunotoxins: Hybrid Molecules Combining High Specificity and Potent CytotoxicityImmunological Reviews, 1982
- Monoclonal antibodies to epithelium‐specific components of the human milk fat globule membrane: Production and reaction with cells in cultureInternational Journal of Cancer, 1981
- Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule.The Journal of Experimental Medicine, 1981
- Medulloblastoma.Treatment results and effect on normal tissuesCancer, 1979