Rate-Controlled Drug Delivery
- 29 July 1982
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 307 (5) , 286-290
- https://doi.org/10.1056/nejm198207293070505
Abstract
THE goal of pharmaceutical research is to find drugs with desirable therapeutic properties and low risks of undesirable side effects. Drugs with such high therapeutic ratios are usually sought as new chemical entities — molecules designed to produce the desirable effects without the undesirable ones. However, another method of achieving the goal of pharmaceutical research is through the development of drug-delivery systems that achieve pharmacologic selectivity not solely on the basis of chemical structure but also on the basis of pharmacokinetic principles. Drug products achieving controlled rates of delivery offer one such approach. A few of these are already available . . .Keywords
This publication has 18 references indexed in Scilit:
- The Use of an Implantable Insulin Pump in the Treatment of Type II DiabetesNew England Journal of Medicine, 1982
- Transdermal scopolamine in the prevention of motion sickness at seaClinical Pharmacology & Therapeutics, 1981
- Intraarterial infusion chemotherapy for hepatic carcinoma using a totally implantable infusion pumpCancer, 1980
- Morphine: controlled trial of different methods of administration for postoperative pain relief.BMJ, 1980
- RESTORATION OF NORMAL LIPID AND AMINOACID METABOLISM IN DIABETIC PATIENTS TREATED WITH A PORTABLE INSULIN-INFUSION PUMPThe Lancet, 1979
- Correlation between plasma diphenhydramine level and sedative and antihistamine effectsClinical Pharmacology & Therapeutics, 1978
- Continuous Subcutaneous Administration of Deferoxamine in Patients with Iron OverloadNew England Journal of Medicine, 1977
- Transient cardiac arrhythmias after single daily maintenance doses of digoxinClinical Pharmacology & Therapeutics, 1976
- Effect of dosage regimen on natriuretic response to furosemideClinical Pharmacology & Therapeutics, 1975
- Serum Drug Concentrations as Therapeutic GuidesNew England Journal of Medicine, 1972