Carcino-Embryonic Antigens, Oestrogen Receptors and Androgen Receptors in Human Breast Tumours. Clinical evaluation of carcino-embryonic antigen, IV

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Abstract
In extracts of metastatic breast tumors 2 groups can be distinguished: those with CEA (carcinoembryonic antigen) values higher or lower than 1.5 .mu.g/g protein. The group of tumors with a CEA level exceeding 1.5 .mu.g/g (CEA-positive) included a significantly larger percentage of estrogen receptor-positive tumors than the group with lower CEA levels (CEA-negative). CEA-negative metastases are most likely to be found in patients who fail to respond to hormonal therapy. No relation was demonstrable between the presence of androgen receptors and the CEA level. All possible permutations of CEA, estrogen receptors and androgen receptors were encountered in the tumors examined.