MONOCYTE INVITRO FUNCTION IN SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) .3. BACTERICIDAL ACTIVITY IN PRESENCE OF SLE-SERA

  • 1 January 1980
    • journal article
    • research article
    • Vol. 31, 53-55
Abstract
The bactericidal activity [vs. Staphylococcus aureus] of normal monocytes in the presence of serum from 14 patients with SLE [systemic lupus erythematosus] was studied with a modification of the Maaloe technique. The bactericidal activity was impaired in the presence of sera from 8/14 patients. The group with abnormal bacterial killing showed higher clinical activity than did the group with normal killing capacity. Corticosteroid therapy was more common among patients with reduced killing. Patients with reduced killing had more episodes of infection during a 2 yr follow-up.

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