Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
- 7 August 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 46 (19) , 4009-4020
- https://doi.org/10.1021/jm030843b
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Structures of Nitroreductase in Three StatesJournal of Biological Chemistry, 2002
- The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolutionJournal of Molecular Biology, 2001
- The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: Induction of bystander killing in vitro and in vivoCancer Gene Therapy, 2000
- Arrays with Local Centers of Symmetry in Space Groups Pca21 and Pna21Acta crystallographica Section B, Structural science, crystal engineering and materials, 1998
- 1.8 Å crystal structure of the major NAD(P)H:FMN oxidoreductase of a bioluminescent bacterium, Vibrio fischeri: overall structure, cofactor and substrate-analog binding, and comparison with related flavoproteinsJournal of Molecular Biology, 1998
- Mustard Prodrugs for Activation by Escherichia coli Nitroreductase in Gene-Directed Enzyme Prodrug TherapyJournal of Medicinal Chemistry, 1997
- Crystallization and Preliminary Crystallographic Data for an FMN-dependent Nitroreductase from Escherichia coli BJournal of Molecular Biology, 1994
- PROCHECK: a program to check the stereochemical quality of protein structuresJournal of Applied Crystallography, 1993
- Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cellsJournal of Medicinal Chemistry, 1992
- Free R value: a novel statistical quantity for assessing the accuracy of crystal structuresNature, 1992