Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia
Top Cited Papers
- 2 July 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 305 (5680) , 90-93
- https://doi.org/10.1126/science.1098925
Abstract
Analysis of developmental plasticity of bone marrow–derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs without cell-cell fusion. We use the Cre/lox system together with β-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion.Keywords
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