Effects of Chronic Prazepam Administration on Drug Metabolism in Man and Rat
- 1 January 1972
- journal article
- clinical trial
- Published by S. Karger AG in Pharmacology
- Vol. 7 (3) , 197-206
- https://doi.org/10.1159/000136289
Abstract
Chronic administration of prazepam produced opposite effects on drug metabolism in man and rat. After an oral dose of 10 mg t.i.d. for 7 days, prazepam prolonged antipyrine half-lives in all but 1 of 12 healthy Negro volunteers. In 5 of these subjects who also received a single dose of 14C-prazepam before and after the 7-day course of unlabelled prazepam, the plasma half-life of 14C-prazepam wasKeywords
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