The Vanilloid Receptor TRPV1 Is Tonically ActivatedIn Vivoand Involved in Body Temperature Regulation
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Open Access
- 28 March 2007
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 27 (13) , 3366-3374
- https://doi.org/10.1523/jneurosci.4833-06.2007
Abstract
The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons (pH in vivoand that TRPV1 antagonism and hyperthermia are not separable. TRPV1 antagonists caused hyperthermia in multiple species (rats, dogs, and monkeys), demonstrating that TRPV1 function in thermoregulation is conserved from rodents to primates. Together, these results indicate that tonic TRPV1 activation regulates body temperature.Keywords
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