Genotypes and Sequence Variants of Human Papillomavirus DNAs from Human Immunodeficiency Virus Type I-Infected Women with Cervical Intraepithelial Neoplasia

Publisher Website
Google Scholar
Abstract
Human papillomavirus (HPV) DNA was found in cervicovaginallavage fluids from 9 of 11 human immunodeficiency virus type 1 (HIV-I)-seropositive female prostitutes with cervical intraepithelial neoplasia (CIN) in Kinshasa, Zaire. Since 7 yielded complex nucleic acid hybridization results consistent with mixed HPV infections,limited sequencingofHPV DNA was used to identify the HPVs present. Three of HPV 16 and 1 each of HPV 18, 31, 33, and S6 and MEI80-HPV were identified by sequencing in 8 samples. Each of these genotypes has been found in specimens from HIV-I-seronegative women with CIN. Some DNAs had nucleic acid and amino acid sequencevariations relative to the referenceHPVs, but the variants were closely related to variants that have been found in HIV-I-seronegative women. Variant amino acids were found predominantly at three positions in one 40-amino-acid segment of the LI open reading frame sequenced. The predominant HPV 16 variant observed has been found rarely in other countries.

This publication has 0 references indexed in Scilit: