The Structure-Activity Relationships in Coronatine Analogs and Amino Compounds Derived from (+)-Coronafacic Acid
- 1 August 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 43 (8) , 1753-1757
- https://doi.org/10.1080/00021369.1979.10863680
Abstract
To investigate the active site of coronatine, the coronatine stereoisomers and analogs were synthesized by replacing the coronamic acid moiety with other amino compounds. The hypertrophy response of potato tubers was used for the bioassay of the compounds. A carboxyl group in coronamic acid was indispensable for the induction of activity. Moreover, the configuration of .alpha.-carbon atom in the amino acid was closely related to increase in activity. Some alkyl groups of the amino acid also influenced the activity.This publication has 2 references indexed in Scilit:
- Facile Stereoselective Synthesis of (+)- and (−)-Allocoronamic AcidsAgricultural and Biological Chemistry, 1977
- Isolation and structure of a chlorosis-inducing toxin of Pseudomonas phaseolicolaPhytochemistry, 1976