Retinoic acid-binding protein in human squamous cell carcinomas of the ORL region
- 15 February 1982
- Vol. 49 (4) , 619-622
- https://doi.org/10.1002/1097-0142(19820215)49:4<619::aid-cncr2820490402>3.0.co;2-v
Abstract
In some squamous cell carcinomas of the otorhinolaryngologic region with different grades of differentiation, a protein was found that specifically binds vitamin A acid. In 28 of 37 tumors, the retinoic acid-binding sites were found in significant amounts, according to the authors' data. Areas with metastases showed a lower incidence of retinoic acid-binding, whereas in all normal epiglottis and vocal cord tissue specimens the binding was present. The possible significance of the protein-binding for the biologic effect of the vitamin A acid is discussed.This publication has 17 references indexed in Scilit:
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