Emetine resistance in Chinese hamster cells is linked genetically with an altered 40S ribosomal subunit protein, S20.
- 1 January 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (1) , 415-419
- https://doi.org/10.1073/pnas.76.1.415
Abstract
Emr-2 is an emetine-resistant (Emr) Chinese hamster ovary cell mutant that contains a single electrophoretically altered ribosomal protein, a component of its 40S ribosomal subunit (Boersma et/al, 1979). A genetic experiment designed to test linkage between the genes that specify the altered ribosomal protein, S20*, and emetine resistance in Emr clones that segregated from cultures of Emr-2 cells hybridized with emetine-sensitive cells is described. Emr and S20* phenotypes are due to mutations linked to the same chromosome in the Chinese hamster genome; probably due to the same mutation. Earlier speculations that the Emr locus in Chinese hamster cells is hemizygous are confirmed.This publication has 13 references indexed in Scilit:
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