CHARACTERIZATION OF HUMAN TERATOMA CELL LINES FOR THEIR IN VITRO DEVELOPMENTAL PROPERTIES AND EXPRESSION OF EMBRYONIC AND MAJOR HISTOCOMPATIBILITY LOCUS‐ASSOCIATED ANTIGENS

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Abstract
Human teratoma cell lines [Tera I, Tera II, Huttke, PA I and SuSa] were characterized for the presence of a certain number of marker antigens whose presence or absence was characteristic of mouse embryonal carcinoma (EC) cells. Of the 5 lines, 4 respond to at least some of the criteria associated with murine EC cells even though only limited in vitro differentiation was demonstrated. The significance of certain unusual marker antigen combinations present on the cell line Tera I and its clones and so far unobserved for the murine model is discussed. The observation in Tera I populations of cells carrying simultaneously both the F9 and .beta.2-microglobulin or HLA antigens, suggest that the human cell lines may represent a novel material for the study of mammalian differentiation.