The Precipitating Antibody to an Acidic Nuclear Protein Antigen, the Jo‐1, in Connective Tissue Diseases

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Abstract
The clinical significance of antibodies to the Jo‐1 antigen in connective tissue diseases was studied. Clinical diagnoses of 11 patients who had anti‐Jo‐1 antibody were: polymyositis 8, dermatomyositis 1, and overlap syndrome 2 (polymyositis‐systemic lupus erythematosus 1, polymyositis—scleroderma 1). All the patients who had anti‐Jo‐1 antibody showed interstitial pulmonary fibrosis, and in 2 patients anti‐Jo‐1 antibodies were detected before the appearance of lung disease.