Diabetes in Mice after Coxsackie B4 Virus Infection
- 7 July 1973
- Vol. 3 (5870) , 25-27
- https://doi.org/10.1136/bmj.3.5870.25
Abstract
The intraperitoneal inoculation of CD1 mice with Coxsackie virus B4 resulted in the raising of blood sugar levels to diabetic values 12 days after the administration of the virus. Serum insulin remained inappropriately low. Light microscopy changes in the islets of Langerhans showed mononuclear cell infiltration of the islets and marked degranulation of the β cells. The acinar tissue appeared to be little changed. It is concluded that Coxsackie B4 virus may cause a diabetic state compatible with islet cell damage.Keywords
This publication has 5 references indexed in Scilit:
- Pancreatic islet cell damage in mice produced by coxsackie B1 and encephalomyocarditis virusesCellular and Molecular Life Sciences, 1972
- Seasonal Incidence of Diabetes MellitusBMJ, 1969
- Viral Antibodies in Diabetes MellitusBMJ, 1969
- Diabetes Mellitus: Induction in Mice by Encephalomyocarditis VirusScience, 1968
- Immunoassay of insulin with insulin-antibody precipitateBiochemical Journal, 1963