Effect of cholecystokinin octapeptide on body temperature in the rat.
- 1 January 1981
- journal article
- research article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 31 (6) , 849-858
- https://doi.org/10.2170/jjphysiol.31.849
Abstract
The C-terminal octapeptide of cholecystokinin (CCK-8) injected into the lateral ventricle of rats produced a lowering of body temperature. CCK-8 potentiated pentobarbital-induced hypothermia, but not the ethanol one. Thyrotropin releasing hormone (TRH) and prostaglandin E2 (PGE2) antagonized the hypothermic effect of CCK-8. Non-sulfated CCK-8 was ineffective in lowering body temperature, indicating sulfated tyrosine in the CCK molecule is indispensable for its hypothermic action. Caerulein possesses less activity compared with CCK-8.This publication has 9 references indexed in Scilit:
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