Immunogenicity of the Group A and Group C Meningococcal Polysaccharides in Children

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Abstract
Forty-eight children, ages seven months to nine and one-half years, were injected subcutaneously with 25 μg or 50 μg of purified polysaccharide vaccine prepared from Neisseria meningitidis of group A (22 children) or group C (26 children). There were no significant local or systemic side effects. All children produced humoral antibodies of immunoglobulin classes G, M, and A within three weeks of immunization as determined by indirect immunofluorescence. The antibodies had bactericidal and hemagglutinating activities. Geometric mean concentrations of antibody (μg of antibody protein/ml), as determined by radioactive-antigen-binding assays, were 10.3 μg for the group receiving the A polysaccharide and 14.5 μg for the group receiving the C polysaccharide. Elevated levels of specific antibody were found in the sera of children 10–15 months after immunization with the group A or the group C antigen.

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