Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient
- 1 March 2010
- journal article
- case report
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 54 (3) , 1360-1362
- https://doi.org/10.1128/aac.01138-09
Abstract
We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.Keywords
This publication has 18 references indexed in Scilit:
- Changes in Karyotype and Azole Susceptibility of Sequential Bloodstream Isolates from Patients with Candida glabrata CandidemiaJournal of Clinical Microbiology, 2007
- Resistance to echinocandin-class antifungal drugsDrug Resistance Updates, 2007
- Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2005: an 8.5-Year Analysis of Susceptibilities of Candida Species and Other Yeast Species to Fluconazole and Voriconazole Determined by CLSI Standardized Disk Diffusion TestingJournal of Clinical Microbiology, 2007
- Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-ResistanceAntimicrobial Agents and Chemotherapy, 2007
- Candida albicans and Candida glabrata Clinical Isolates Exhibiting Reduced Echinocandin SusceptibilityAntimicrobial Agents and Chemotherapy, 2006
- Amphotericin B and Caspofungin Resistance in Candida glabrata Isolates Recovered from a Critically Ill PatientClinical Infectious Diseases, 2006
- Inactivation of the FCY2 Gene Encoding Purine-Cytosine Permease Promotes Cross-Resistance to Flucytosine and Fluconazole in Candida lusitaniaeAntimicrobial Agents and Chemotherapy, 2005
- Mechanisms of Azole Resistance in Clinical Isolates of Candida glabrata Collected during a Hospital Survey of Antifungal ResistanceAntimicrobial Agents and Chemotherapy, 2005
- In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and Cryptococcus neoformans collected during 2001 and 2002 in the ARTEMIS global antifungal surveillance programDiagnostic Microbiology and Infectious Disease, 2004
- Mechanisms of Fungal ResistanceDrugs, 2002