Production and characterisation of a human monoclonal antibody to cytomegalovirus and its use in an early nuclear fluorescence assay
- 1 July 1987
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 22 (3) , 245-255
- https://doi.org/10.1002/jmv.1890220308
Abstract
A human monoclonal antibody to cytomegalovirus (CMV) was produced by transforming peripheral blood mononuclear cells of a patient with recent CMV infection. It is directed against a late antigen located in the nucleus of CMV infected fibroblasts at 24‐72 hours post infection and immuneprecipitates 65K and 48K proteins from 35S‐labelled CMV infected cells. Results of its use in an early nuclear fluorescence assay for rapid diagnosis are presented.Keywords
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