Induction of Cataracts in Mice by Slow Neutrons and X-rays.

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Abstract
Mice were placed in the thermal column of the Oak Ridge reactor during from 2.5 to 80 minutes (LD50) and observed thereafter until natural death. As small a dose as 32 r of total body X-rays caused a slight increase in the % of mice developing opacities of the lens. With larger doses the cataract induction rate approached 100%, the lesions were more severe and the latency period was shorter. The morph. features of the radiation and senile cataracts of mice are described. The cataracts develop in the immature part of the lens (cortex), while the more mature part of it (nucleus) is spared. Slow neutrons are, on basis of LD50 at least twice as effective in inducing cataracts as X-rays.

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