Experience with amikacin and colistin in an outbreak of infection by resistant Klebsiella aerogenes

1 September 1977

journal article
research article
Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy

Vol. 3 (5) , 483-491
https://doi.org/10.1093/jac/3.5.483

Abstract

Of more than 100 hospital patients colonized with a resistant Klebsiella aerogenes strain, 15 required treatment with colistin or amikacin. Colistin failed to eradicate a urinary tract infection in 4 cases, and in 3 cases more resistant isolates were obtained after treatment. Amikacin was successful in all but 1 of 15 episodes of infection (13 by the epidemic strain of K. aerogenes; 2 by other Gram-negative bacilli) in 14 patients. Amikacin is an effective agent which may be used with safety if the serum concentrations are monitored, but it should be reserved for clinically significant infections by bacteria resistant to other antibiotics.

Keywords

This publication has 2 references indexed in Scilit:

Amikacin Therapy for Serious Gram-Negative Bacillary Infections
Annals of Internal Medicine, 1975
Amikacin Therapy for Severe Gram-Negative Sepsis
Annals of Internal Medicine, 1975