Variations in Cell Population of Intestinal Lamina Propria in Relation to Age

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Abstract
C57 Black mice ranging from 28 days to 778 days of age, were used to study the cells of the lamina propria. The types of cells on which quantitative study were made include: endothelial cells, eosinophils, fibroblasts, lymphocytes, plasma cells and unclassified. The 4 regions of small intestine that were distinguished include the proximal duodenum with Brunner''s glands, distal duodenum without Brunner''s glands, jejunum and ileum. Analysis of the data was made using the Tukey-Freeman transformation in a 7040 computer. The variations according to cell type; to region and cell type; and to age and cell type all are highly significant. The most striking age difference was the increase in numbers of plasma cells when very young and mature mice were compared. The most striking regional difference was in the greater numbers of eosinophils in the jejunum as compared with the other regions of the small intestine.