Immunogenetic Analysis of H‐2 Mutations

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Abstract
H-2fa is a spontaneous mutation that occurred in an (A.CA .times. A)F1 female mouse and was later transferred on an A-strain background [congenic line A.CA(M506) or M506]. Skin grafts exchanged between M506 and A.CA strains are rejected within 4 wk after grafting. Significant reaction is observed when these 2 strains are used as responders and stimulators in mixed lymphocyte culture or in a splenomegaly graft-vs.-host assay. The mutant antigen induces strong cell-mediated lymphocytotoxicity. The mutation maps in the K end of the H-2 complex. The capacity of mutant antigens to induce relatively strong lymphocyte proliferation is explained by hypothesizing that the T [thymus-derived]-cell receptors reacting with K- or D-region products can more easily recognize subtle than drastic alloantigenic differences.