‘One-pot’ biomimetic synthesis of 19β-heteroyohimbine alkaloids

1 January 1977

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 18,p. 636-638
https://doi.org/10.1039/c39770000636

Abstract

Tryptamine and secologanin have been converted into akuammigine (7b), tetrahydroalstonine (7a), and ajmalicine (7c), in a highly regio- and stereo-selective sequence of reactions which duplicates the in vivo process; strictosidine (6a) is a precursor for 3α-alkaloids and vincoside (6b) for 3β.