Effects of Methamphetamine on Regional Cerebral Glucose Utilization in Rats with Unilateral Lesion of Substantia Nigra
Open Access
- 1 January 1990
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 53 (3) , 414-418
- https://doi.org/10.1254/jjp.53.414
Abstract
In rats with electrocoagulation of the unilateral subtantia nigra (SN), methamphetamine at doses of 2.5 and 5 mg/kg, i.p., induced ipsilateral turning towards the lesioned side and caused an imbalance of the regional cerebral glucose utilization (CGU) in the caudate-putamen (CP), frontal cortex (FC) and ventromedial thalamic nucleus (VMT); i.e., showing a higher contralateral CGU as compared with the SN lesioned side. These results induced in unilateral SN-lesioned rats may be accompanied by an imbalance of neural activity in CP, FC and VMT of these rats.This publication has 15 references indexed in Scilit:
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