Molecular Identification of Adenoviruses in Clinical Samples by Analyzing a Partial Hexon Genomic Region
Open Access
- 1 December 2005
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (12) , 6176-6182
- https://doi.org/10.1128/jcm.43.12.6176-6182.2005
Abstract
Here we present a system for adenovirus detection and genotyping based on PCR amplification and phylogenetic analysis of a conserved hexon gene fragment. The system was validated using 157 sequences (86 previously typed and 71 clinical samples) and correctly identified species and serotype in 100% and 84% of sequences, respectively. Known associations between specific serotypes and clinical syndromes are verified. Possible new associations are described to allow further independent testing.Keywords
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