COMPARATIVE-STUDY OF CARDIOTOXICITY OF KARMINOMYCIN AND ADRIAMYCIN, ANTHRACYCLINE ANTIBIOTICS ON ALBINO MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 21  (12) , 1106-1113
Abstract
The cardiotoxic effect of carminomicin and adriamycin administered i.v. 5 times in equitoxic doses constituting equal portions of LD50 of the respective antibiotic on its single i.v. administration was studied on albino mice. Histological examination of the heart showed that almost identical damages of the myocardium occurred after administration of carminomicin and adriamycin in doses of 0.45 of LD50 (1.5 mg/kg) and 0.3 of LD50 (6.3 mg/kg), respectively. The character of damages due to antibiotics was similar; most significant changes were observed when animals were sacrificed 1 mo. after last administration of the drug. The histological method is of value in estimation of the cardiotoxic effect of the drugs, using mice as the model suitable for the investigation. Adriamycin had more pronounced cumulative properties as compared to carminomicin:weight gain suppression and higher death rates.

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