SIMULTANEOUS RELEASE OF VASOPRESSIN AND NEUROPHYSINS DURING INFUSION OF NICOTINE IN MEN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 171  (2) , 478-483
Abstract
Using the radioimmunoassay (RIA) for neurophysins (IRN) that was previously described a concomitant, rapid release of ADH and IRN was demonstrated within the first 2 min of i.v. infusion of nicotine in 11 patients with normal neuropituitary function and 1 patient suffering from a Schwartz-Bartter syndrome. There was a close relationship, r : 0.82, P < 0.001) similar to that previously described, between peak levels of ADH and IRN in all patients. The RIA system probably is influenced by nicotine stimulated neurophysins (NSN). The negative results previously found in 5 normal men could have been due to length of the period between the beginning of the test and the 1st blood sampling (30 min.).

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