THE GENE FOR APOLIPOPROTEIN C-II IS CLOSELY LINKED TO THE GENE FOR APOLIPOPROTEIN-E ON CHROMOSOME-19
- 1 January 1984
- journal article
- research article
- Vol. 26 (5) , 389-396
Abstract
A common TaqI restriction fragment length polymorphism (RFLP) near the human apolipoprotein C-II (apoC-II) gene was used to study linkage with apolipoprotein E (apoE). The inheritance of the apoC-II RFLP was followed in 7 families that were segregating for apoE protein variants. No recombinants were observed in 20 informative meioses, giving an overall lod score of > 4.0 at recombination fraction 0. Apparent linkage disequilibrium was also observed between apoE and the apoC-II RFLP. These 2 apolipoprotein genes are closely linked and confirm that the gene for apoC-II is on human chromosome 19.This publication has 4 references indexed in Scilit:
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