Selective Enzymatic Deprotection of Hydroxy- and Amino Groups in Carbohydrates and Nucleosides
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (01) , 65-67
- https://doi.org/10.1055/s-1994-22740
Abstract
The enzyme acetyl esterase from the flavedo of oranges (EC 3.1.1.6) chemo- and regioselectively removes acetyl groups from carbohydrates and nucleosides. The chemoselective enzymatic liberation of the amino functions present in the nucleobases of O-acetylated nucleosides is achieved by penicillin G acylase (EC 3.5.1.11) mediated hydrolysis of the corresponding phenylacetamides.Keywords
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