Benzidine and 3,3'-dichlorobenzidine (DCB) induce micronuclei in the bone marrow and the fetal liver of mice after gavage
- 1 January 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 2 (4) , 267-269
- https://doi.org/10.1093/mutage/2.4.267
Abstract
Single oral dose of benzidine (300 mg/kg) and DCB (1000 mg/kg) to male ICR mice elicited positive response in the bone marrow micronucleus test. In the transplacental micronucleus test, the compounds were administered to pregnant females in the same manner. A significant increase in the frequency of micronuclei occurred in the fetal liver, but not in the bone marrow of mothers. The relative values of bone marrow and transplacental micronucleus tests for the prediction of carcinogenicity of these compounds is discussed.This publication has 8 references indexed in Scilit:
- Slide preparation and sampling as a major source of variability in the mouse micronucleus assayMutation Research/Environmental Mutagenesis and Related Subjects, 1986
- Investigations into parametric analysis of data from in vivo micronucleus assays by comparison with non-parametric methodsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1986
- The unique role of rodents in the detection of possible human carcinogens and mutagensMutation Research/Reviews in Genetic Toxicology, 1983
- Studies on the metabolic activation of benzidine by isolated rat hepatocytesToxicology, 1982
- Short-term tests for transplacentally active carcinogensMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1981
- Further improvements in the hepatocyte primary culture DNA repair test for carcinogens: detection of carcinogenic biphenyl derivativesCancer Letters, 1978
- TESTING OF KNOWN CARCINOGENS AND NONCARCINOGENS FOR THEIR ABILITY TO INDUCE UNSCHEDULED DNA-SYNTHESIS IN HELA-CELLS1978
- An evaluation of the mutagenicity of the cutting oil preservative Grotan BKMutation Research/Genetic Toxicology, 1976