Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
Open Access
- 1 December 1992
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 29 (12) , 858-860
- https://doi.org/10.1136/jmg.29.12.858
Abstract
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).Keywords
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