Waterhouse-Friderichsen Syndrome

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Abstract
THE Waterhouse-Friderichsen syndrome is noted for its intensity, rapidity of progression and extremely grave prognosis. It was considered to be a universally fatal disease until 1940, when Carey1 reported a case ending in recovery. Since then there have been recorded instances of recovery but the mortality remains extremely high. The few instances of recovery have tended to raise a question concerning the diagnosis and to bring up for review the pathological mechanisms of the disease. In addition, the treatment of the condition is far from standardized owing to the poor results obtained with present-day therapy.The earliest pathological reports on . . .