Enantioselective synthesis of monocyclic .BETA.-lactams related to nocardicins via (2+2) cycloaddition reaction.
- 31 December 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (10) , 3985-3994
- https://doi.org/10.1248/cpb.35.3985
Abstract
Monocyclic .beta.-lactams related to nocardicins were enantioselectively synthesized from phthalimidoacetyl chloride and hexahydro-1,3,5-triazines (4) via a [2+2] cycloaddition reaction. The preparation and biological activity of some typical acyl derivatives are also described.This publication has 4 references indexed in Scilit:
- Preparation of 3-aminocardicinic acid and its acyl derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Total synthesis of monocyclic β-lactam antibiotics, nocardicin A and DTetrahedron, 1979
- Nocardicin A, a new monocyclic .BETA.-lactam antibiotic. II. Structure determination of nocardicins A and B.The Journal of Antibiotics, 1976
- Nocardicin a, a new monocyclic .BETA.-lactam antibiotic. I. Discovery, isolation and characterization.The Journal of Antibiotics, 1976