Inducer-Specific Regulators of Tumor Necrosis Factor Alpha Production.

1 January 1996

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 44 (10) , 1980-1982
https://doi.org/10.1248/cpb.44.1980

Abstract

Novel potent regulators of tumor necrosis factor alpha (TNF-alpha) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-alpha production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-alpha production, while they inhibited okadaic acid-induced one.

Keywords

BIDIRECTIONAL
LEUKEMIA
TUMOR NECROSIS
OKADAIC
PROMYELOCYTIC
TETRADECANOYLPHORBOL
ALPHA PRODUCTION

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