Substituted (Pyridylmethoxy)naphthalenes as Potent and Orally Active 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Pharmacokinetics of L-739,010
- 1 August 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 40 (18) , 2866-2875
- https://doi.org/10.1021/jm970046b
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Lipidosis Induced in the Dog Gallbladder by a Direct 5-Lipoxygenase InhibitorToxicologic Pathology, 1996
- Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic StabilityJournal of Medicinal Chemistry, 1996
- Microsomal Metabolism of the 5-Lipoxygenase Inhibitor L-739,010: Evidence for Furan BioactivationChemical Research in Toxicology, 1996
- Naphthalenic Lignan Lactones as Selective, Nonredox 5-Lipoxygenase Inhibitors. Synthesis and Biological Activity of (Methoxyalkyl)thiazole and Methoxytetrahydropyran HybridsJournal of Medicinal Chemistry, 1994
- The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheepEuropean Journal of Pharmacology, 1992
- Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitorsJournal of Medicinal Chemistry, 1992
- Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitorCanadian Journal of Physiology and Pharmacology, 1992
- Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1990
- Inhibition of allergen-induced bronchoconstriction in hyperreactive rats as a model for testing 5-lipoxygenase inhibitors and leukotriene D4 receptor antagonistsInflammation Research, 1987
- The synthesis of some substituted methyl pyridinecarboxylates. II. Methyl 4-substituted picolinates, methyl 5-substituted picolinates, and methyl 5-substituted nicotinatesAustralian Journal of Chemistry, 1971