Preparation of a Stable Intravenous Gamma‐Globulin: Process Design and Scale‐Up
- 1 August 1980
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 39 (2) , 101-112
- https://doi.org/10.1111/j.1423-0410.1980.tb01844.x
Abstract
I.v. .gamma.-globulin was prepared on a pilot scale by the process of reduction with dithiothreitol and alkylation with iodoacetamide. The spent reagents are removed by diafiltration followed by ultrafiltration. The product is stabilized with maltose to minimize precipitation. Process design concepts and product characteristics are discussed.This publication has 17 references indexed in Scilit:
- EPIDEMIC HEPATITIS B CAUSED BY COMMERCIAL HUMAN IMMUNOGLOBULINThe Lancet, 1979
- Intravenous γ-Globulin Infusions in Patients with Hypo-γ-GlobulinemiaVox Sanguinis, 1978
- Development of an Intravenous γ‐Globulin with Fc ActivitiesVox Sanguinis, 1977
- Hepatitis B in Subjects Treated with a Drug Containing ImmunoglobulinsThe Journal of Infectious Diseases, 1977
- Antibody to the Hepatitis B Surface Antigen in Immune Serum GlobulinTransfusion, 1975
- Undegraded Human Immunoglobulin for Intravenous UseVox Sanguinis, 1975
- Optically active dithiothreitol. Toxicity and radiation-protective activityJournal of Medicinal Chemistry, 1972
- Intravenous Administration of Human γ‐Globulin*Vox Sanguinis, 1962
- The Separation of the Antibodies, Isoagglutinins, Prothrombin, Plasminogen and β1-Lipoprotein into Subfractions of Human PlasmaJournal of the American Chemical Society, 1949
- Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids1a,b,c,dJournal of the American Chemical Society, 1946