Studies on the ionophorous antibiotics. VIII. Effects of monovalent and divalent cation ionophores on blood platelets.

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Abstract
The effects of a monovalent cation ionophore etheromycin (CP-38295) and a divalent cation ionophore lysocellin on blood platelet [rabbit] function was investigated. When platelets were incubated with 3 .mu.M of each ionophore, the simultaneous induction of secretion of stored serotonin and efflux of intracellular Ca occurred, but there was no detectable influx of extracellular Ca. With increasing concentrations, these compounds caused platelet aggregation accompanied by increased influx of external Ca. These results are consistent with the hypothesis that the liberation of Ca from the intracellular store mediates the platelet secretion reaction.