Muscle Fasciculations in a Healthy Population

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Abstract
Introduction The occurrence of muscle fasciculations in an otherwise healthy person is not regarded as the ominous prelude to a progressive lower motor neuron disease as it was 20 years ago. Several reports document the fact that many persons experience fasciculations over a period of years, and the occurrence is without pathological significance.1-3 In regard to this change in clinical impression, it is surprising that no definitive investigation has been made to determine the extent to which healthy persons experience fasciculations. This report is an analysis of the occurrence of benign muscle fasciculations in a large group of healthy medical personnel. There is confusion and difference of opinion in the literature concerning the terminology describing benign and pathological fasciculations. When seen with amyotrophic lateral sclerosis and related conditions, fasciculations are considered a true sign of pathology of the motor nuclei of the brain stem or the anterior horn

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