Peroxidation of Phospholipids Promoted by Myeloperoxidase
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 4 (4) , 251-257
- https://doi.org/10.3109/10715768809055150
Abstract
Myeloperoxidase was found to promote peroxidation of phospholipids under acidic conditions in the presence of hydrogen peroxide and iodide ions The peroxidation was markedly enhanced by pyrophosphate-chelated ferric iron and was inhbited by desferrioxamine and superoxide dismutase. This observation adds lipid peroxidation to the oxidative damage caused by myeloperoxidase, which is a phagocytic cell enzyme involved in phapocyte-mediated cell destruction.Keywords
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