NUCLEOLI OF LYMPHOCYTES IN PERIPHERAL-BLOOD OF PATIENTS WITH BRONCHOGENIC LUNG AND GASTROINTESTINAL CANCER

  • 1 January 1976
    • journal article
    • research article
    • Vol. 23  (2) , 183-190
Abstract
Patients with bronchogenic and gastrointestinal cancer without and with metastases were investigated to provide more information on the number and morphology of lymphocytes in their peripheral blood with respect to the frequency of various nucleolar types in these cells. The decreased number of lymphocytes in the peripheral blood of cancer patients was due to the decline of lymphocytes with ring shaped nucleoli representing resting cells which can be stimulated with respect to RNA synthesis and blast transformation. The decreased number of such cells was more pronounced in the peripheral blood of patients with gastrointestinal cancer with metastases. The increased frequency of lymphocytes with compact nucleoli or nucleoli with nucleolonemas representing immature or stimulated cells was noted in most patients with bronchogenic cancer without and with metastases in lymph nodes, as well as in some patients with gastrointestinal cancer without metastases. Decreased numbers of these cells was observed in the peripheral blood of patients with gastrointestinal cancer with metastases. All these changes provide further information on the changes of lymphocytes in the peripheral blood of patients with malignant disease. The possible interpretation of these changes presented in the discussion is in accordance with the present conception on the relationship between malignant growth and lymphocytes.

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