Chromosomal breakage in normal and fragile X subjects using low folate culture conditions.

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Abstract
To investigate whether the fragile X syndrome is associated with a generalized chromosomal instability, the frequency and distribution of chromosomal breakage in lymphocytes grown in low folate medium from normal subjects and from patients with the syndrome were compared. Although low folate conditions increased the rate of chromosome breakage, no difference in frequency or distribution of chromosomal breakage was found between the 2 groups. The fragile X syndrome is evidently not associated with a generalized chromosome instability expressed in folate deficient medium and assessed in terms of chromosomal breakage.