IMMUNITY AND TOLERANCE TO EMBRYONIC TAIL ALLOGRAFTS IN THE LEOPARD FROG

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Abstract
SUMMARY Portions of embryonic tail tissue transplanted before functional maturation of the host's immune system do not survive indefinitely. Small allografts of tail tissue evoke an immune response, whereas large tail transplants induce a state of tolerance. Hosts that had earlier rejected small tail transplants vigorously destroyed test skin grafts in typical second-set fashion, while hosts bearing large, viable tail allografts tolerated subsequent skin grafts from the original donors. Donor origin skin grafts were tolerated beyond metamorphosis after resorption of the tolerance-inducing tail graft. Donor leukocytes were found in the circulation of diploid juvenile frogs grafted with large triploid tail grafts. Although these observations suggest antigen sharing between lymphocytes and skin in the frog and, further, implicate donor lymphocytes as the source of persisting antigen, the role of serum factor(s) which mediate tolerance may also be important in this system

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