Chitin Biosynthesis Enhancement by the Endochitinase Inhibitor Allosamidin
- 31 December 1989
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 371 (1) , 471-474
- https://doi.org/10.1515/bchm3.1990.371.1.471
Abstract
Membrane preparations of Artemia salina synthetize radiolabelled chitin from UDP-[U-14C]-GlcNAc at a low rate (Horst, M.N. (1981) J. Biol. Chem. 256, 1412-1419). We now report that, when the specific endochitinase inhibitor allosamidin is present in addition to the established activators trypsin and GlcNAc, incorporation of [U-14C]GlcNAc into chitin is increased up to 58-fold over the basic synthesis rate. thus, a greatly enhanced apparent chitin synthase activity is observed in membranes from an arthropod species when simultaneous degradation of chitin is inhibited.This publication has 7 references indexed in Scilit:
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