Influence of specific activity on myocardial uptake of 123I-mIBG in rats
- 1 September 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Nuclear Medicine Communications
- Vol. 9 (9) , 663-668
- https://doi.org/10.1097/00006231-198809000-00009
Abstract
Heart and lung uptake of 123I-mIBG was studied in rats l h after injection as a function of specific activity (mCi mg−1) and the total loading dose (μg kg−1) of labelled compound. Absolute lung uptake of the tracer was dependent upon specific activity, declining as the loading dose increased from 0.15 to 4300 (μg kg−1. Uptake in the total heart was constant at 2.1% up to about 12 μg kg−1, at which point the heart uptake also began to decline as the loading dose increased. Myocardial uptake of 123I-mIBG, therefore, appears saturable in the rat and subject to competitive binding and/or displacement with increasing amounts of non-labelled compound.Keywords
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