Endogenous Cathepsin Activation of Trypsinogen in Extracts of Dog Pancreas.
- 1 May 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 107 (1) , 74-76
- https://doi.org/10.3181/00379727-107-26539
Abstract
Evidence is presented that endogenous trypsinogen in extracts of dog pancreas is activated under the same conditions that cathepsin B activates trypsinogen in vitro (J. Biol. Chem. 1959, v234, 2885). The activation occurs at pH 3.6 and is enhanced by cysteine and is inhibited by iodo-acetic acid. The tentative conclusion reached is that cathepsin B-like enzymes in pancreas are catalyzing the reaction. The possible clinical implications of such reactions is discussed.Keywords
This publication has 3 references indexed in Scilit:
- The Activation of Trypsinogen by Cathepsin BJournal of Biological Chemistry, 1959
- PURIFICATION AND PROPERTIES OF BEEF SPLEEN CATHEPSIN BJournal of Biological Chemistry, 1957
- IDENTIFICATION OF A PEPTIDE RELEASED DURING AUTOCATALYTIC ACTIVATION OF TRYPSINOGENJournal of Biological Chemistry, 1955