Inhibition of Brain Respiration in vitro by Bilirubin. Reversal of Inhibition By Various Means.

1 February 1954

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 85 (2) , 261-264
https://doi.org/10.3181/00379727-85-20849

Abstract

Bilirubin added to the ambient fluid in concns, above 20-25 mg.% depresses the respiration of chopped rat brain by approx. 25%. This inhibition can be counteracted by oxidation of the bilirubin and by the action of methylene blue on the bilirubin. Cytochrome C also reverses the inhibition. The mechanisms of these reversals appear to be different.

Keywords

BILIRUBIN/EFFECTS
BRAIN/METABOLISM
CYTOCHROMES
METHYLENE BLUE/EFFECTS
OXIDATION-REDUCTION

This publication has 3 references indexed in Scilit:

Erythroblastosis Fetalis
New England Journal of Medicine, 1952
CONGENITAL FAMILIAL NONHEMOLYTIC JAUNDICE WITH KERNICTERUS
1952
KERNICTERUS - ETIOLOGIC STUDY BASED ON AN ANALYSIS OF 55 CASES
1950