Connecting signaling and cell cycle progression in growth factor-stimulated cells
- 20 November 2000
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 19 (49) , 5558-5567
- https://doi.org/10.1038/sj.onc.1203858
Abstract
A widely used model system to investigate cell proliferation is stimulation of serum-arrested cells with growth factors. Recent data suggest that there are two waves of growth factor-dependent signaling events required for a proliferative response. One is an acute burst of signaling, which occurs immediately after growth factor stimulation and lasts for 30 - 60 min. The other occurs in a different time frame (8 - 12 h post stimulation), and involves activation of cyclin dependent kinases (Cdks). In addition to a general overview of growth factor-dependent signaling, we present our 'two wave' hypothesis for how signaling and cell cycle progression are linked.Keywords
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