Interferon as an adjuvant for hepatitis B vaccination in non- and low-responder populations

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Abstract
To determine the effect of interferon on the production of antibodies against hepatitis B virus, recombinantα-interferon was added only to the fifth vaccine injection in a non-responder group and to all three initial vaccine injections in a low-responder group. In the non-responder group, 27 % of the hemodialysis patients, 7 % of the renal transplant patients, and both medical staff members tested developed low serum concentrations of anti-HBs (< 25 mU/ml). Whereas in the low-responder group 60 % of the hemodialysis patients developed the same amount of antibodies as a placebo group of comparable patients (⩾ 25 mU/ml), 78% of the renal transplant patients showed a 25 % higher antibody concentration than a placebo group (half < 25 mU/ml;half < 50 mU/ml). According to these preliminary findingsα-interferon may have an adjuvant effect on hepatitis B vaccination.