THE ALIMENTARY ABSORPTION OF DIAMORPHINE AND MORPHINE IN MAN AS INDICATED BY URINARY EXCRETION STUDIES
Open Access
- 1 December 1974
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 1 (6) , 491-494
- https://doi.org/10.1111/j.1365-2125.1974.tb01699.x
Abstract
1 Urine was collected over 24 h from 40 patients with advanced malignant disease who had received a known four-hourly oral dose of either diamorphine or morphine in an elixir or of diamorphine by injection for at least 3 days. 2 Samples were assayed for total urinary morphine (free and conjugated) by gas-liquid chromatography. 3 The percentage of the administered dose recovered as morphine was: (a) diamorphine hydrochloride by injection: 70% (s.d. 25) (b) diamorphine hydrochloride by mouth: 77% (s.d. 27) (c) morphine sulphate by mouth: 56% (s.d. 21) 4 It is suggested that diamorphine hydrochloride is completely absorbed by the ***gastro-intestinal tract but that morphine sulphate is only some two-thirds absorbed.Keywords
This publication has 6 references indexed in Scilit:
- The quantitative determination of morphine in urine by gas-liquid chromatography and variations in excretionClinica Chimica Acta; International Journal of Clinical Chemistry, 1974
- Actions and metabolism of heroin administered by continuous intravenous infusion to manClinical Pharmacology & Therapeutics, 1971
- Excretion of Morphine in the Urine of Non‐Addicts.Acta Pharmacologica et Toxicologica, 1957
- Excretion of Carbon-14 by Man after Administration of Morphine-N-Methyl-C14Experimental Biology and Medicine, 1954
- [Morphine excretion in opium smokers and normal subjects].1950
- Über die Morphinausscheidung von Opiumrauchern und NormalenNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1950